Low-Dose Whole-Body Irradiation Induced Radioadaptive Response in C57BL/6 Mice

Low-dose whole-body irradiation induced radioadaptive response in C57BL/6 mice.

Radioadaptive survival responses after relatively low doses of radiation were investigated in C57BL/6 mice. The 8-week-old mice received whole-body mid-lethal challenging irradiation (5.9 Gy) at various intervals after conditioning whole-body irradiation with 50-400 mGy. Thereafter, survival of the mice was observed for 30 days. The mice receiving 400 mGy at 6 h before the challenging dose had ...

Prevention of ischemia-reperfusion injury in mice kidneys by low-dose whole body irradiation preconditioning.

TO THE EDITOR: The article recently published by Kim and coworkers (3) is very interesting and presents a new modality for the prevention of ischemia-reperfusion (I/R) injury in the mouse kidney. The authors have reported that whole body irradiation preconditioning (IP) of the animals with an acute single dose at 8 Gray (Gy) protects the kidney more efficiently compared with fractionate doses a...

Exacerbation of autoimmune thyroiditis by a single low-dose of whole-body irradiation in non-obese diabetic-H2 mice

Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2h4 mice.

PURPOSE To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism. MATERIALS AND METHODS Non-obese diabetic (NOD)-H2(h4) mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with sodium iodine (NaI) in the drinking water. BALB/c mice develop anti-thyrotropin receptor (TSHR) antibodies ...

Low-dose irradiation alters the transcript profiles of human lymphoblastoid cells including genes associated with cytogenetic radioadaptive response.

Low-dose ionizing radiation alters the gene expression profiles of mammalian cells, yet there is little understanding of the underlying cellular mechanisms responsible for these changes or of their consequences for genomic stability. We investigated the cytogenetic adaptive response of human lymphoblastoid cell lines exposed to 5 cGy (priming dose) followed by 2 Gy (challenge dose) compared to ...